A New One Step Indole Synthesis.

A NEW STRATEGY FOR THE SYNTHESIS OF TRICYCLIC AND TETRACYCLIC SYSTEMS OF INDOLE ALKALOIDS

Reaction of tryptamine 1 with dimethyl -3-methoxyallylidenemalonate 2 afforded N?-[4,4-bis (methoxycarbonyl)-1,3-butadienyl] tryptamine 3 which in combination with acetylchloride and pyridine in dichloromethane gave N?, N?-[acetyl]-[(4,4-dinethoxycarbonyl) 1,3butadienyl] tryptamine 4. Treatment of 3 with sodium hydroxide afforded 2H[N-(3-indolyl) ethyl] 2-oxo-3-methoxycarbonyl-1-pyridine 5. Cy...

One-step synthesis of novel glycosyltransferase inhibitors.

A one-step synthesis of two 5-CF(3) UDP-sugars is reported. These non-natural sugar-nucleotides are micromolar inhibitors of two different galactosyltransferases.

Domino cyclodimerization of indole-derived donor-acceptor cyclopropanes: one-step construction of the pentaleno[1,6-a,b]indole skeleton.

Bisindoles represent an extensive group of both naturally occurring and synthetically available compounds with a broad range of biological activities, such as antitumor, antiviral, and antibacterial activities. To date, over 200 bisACHTUNGTRENNUNGindole alkaloids have been isolated from various natural sources (Figure 1). Furthermore, considerable attention is currently being paid to the develo...

synthesis of benzyl indole derivatives as new antiplatelet agents

One step forward